Mapping the Trajectory of Functional Decline in Newly Diagnosed Alzheimer's Disease Lead Investigator: Joseph Coughlin Institution : Massachusetts Institute of Technology E-Mail : coughlin@mit.edu Proposal ID : 324 Proposal Description: Due to the fact that the progression of AD has displayed significant inter-patient variability, there is a lack of practical information provided for patients and caregivers regarding the timeline of functional decline. We will use functional (FAQ) and global (CDR) measures to track longitudinal decline in a newly diagnosed AD population as it relates to specific functional questions relevant to patients and caregivers. We eventually seek to develop a tool that will address patient and caregiver concerns by predicting a patient-specific trajectory of functional decline based on patient information provided upon diagnosis.